Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will reduce the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.
pentobarbital will lower the level or effect of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Animal info. Phenobarbital sodium is carcinogenic in mice and rats immediately after lifetime administration. In mice, it made benign and malignant liver mobile tumors. In rats, benign liver mobile tumors were observed really late in life.
pentobarbital will minimize the extent or effect of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Effect of coadministering a solid CYP3A4 inducer with fedratinib has not been examined.
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates around the metabolism of phenytoin seems being variable. Some investigators report an accelerating effect, when others report no effect. As the effect of barbiturates within the metabolism of phenytoin isn't predictable, phenytoin and barbiturate blood ranges ought to be monitored more usually if these drugs are specified concurrently.
pentobarbital will minimize the level or effect of ramelteon by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Unfamiliar.
pentobarbital will minimize the level or effect of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the extent or effect of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will decrease the level or effect of dapsone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
pentobarbital will minimize the level or effect of ambrisentan by influencing read more hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
Observe Closely (one)pentobarbital will lessen the extent or effect of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the extent or effect of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital and olopatadine intranasal both equally boost sedation. Stay away from or Use Alternate Drug. Coadministration will increase danger of CNS melancholy, which can result in additive impairment of psychomotor performance and bring about daytime impairment.
Acute or chronic pain: Warning need to be exercised when barbiturates are administered to clients with acute or Persistent discomfort, because paradoxical pleasure could be induced or significant symptoms might be masked.